Fig. 2. Kaplan–Meier curves and Cox regression analyses depicting the duration until the development of cognitive impairment in PDGBA people stratified by inflammatory profiles.
a–f Kaplan–Meier analyses of the most relevant inflammatory markers (ICAM-1, interleukin-8, MCP-1, MIP-1 beta, SCF and VEGF) revealed no significant impact on the duration until the development of cognitive impairment. However, adjusting the model for age, sex and disease duration as additional interacting co-variates MIP-1-beta showed a significant effect on the duration until the development of cognitive impairment in Cox regression analyses. Fifty percent of patients with high CSF levels of MIP-1-beta at baseline (third tertile) reached this clinical endpoint after 17 years compared to 13 years in patients with low levels (first tertile).