Table 3.
Correlation between CSF inflammatory markers with CSF PD-biomarkers in people with Parkinson´s disease.
| Aβ1-42 | t-Tau | p181-Tau | NFL | α-synuclein | |
|---|---|---|---|---|---|
| ICAM-1 |
t: 0.101* n = 470 m: 0.134* n = 301 |
t: 0.278*** n = 470 m: 0.274*** n = 301 f: 0.320*** n = 169 |
t: 0.217*** n = 463 m: 0.195*** n = 298 f: 0.277*** n = 165 |
t: 0.211*** n = 445 m: 0.188*** n = 287 f: 0.245** n = 158 |
t: 0.211*** n = 454 m: 0.222*** n = 290 f: 0.236** n = 164 |
| Interleukin-4 | t: 0.127* n = 299 | ||||
| Interleukin-6 | f: 0.214* n = 92 | n.s. | n.s. | m: 0.224** n = 193 | |
| Interleukin-8 |
t: 0.154*** n = 475 m: 0.135* n = 304 f: 0.186* n = 171 |
t: 0.143** n = 475 m: 0.147** n = 304 f: 0.156* n = 171 |
t: 0.105* n = 468 |
t: 0.194*** n = 451 m: 0.241*** n = 291 f: 0.159* n = 160 |
n.s. |
| Interleukin-18 | f: 0.206* n = 121 | n.s. | n.s. | n.s. | n.s. |
| MCP-1 |
t: 0.121** n = 475 f: 0.154* n = 177 |
t: 0.141** n = 475 m: 0.181** n = 304 |
t: 0.105* n = 468 m: 0.120* n = 304 |
t: 0.124** n = 451 m: 0.174** n = 291 |
n.s. |
| MIP-1 alpha | n.s. | n.s. | n.s. | n.s. | t: 0.171* n = 182 |
| MIP-1 beta |
t: 0.140*** n = 477 m: 0.150** n = 306 |
t: 0.279*** n = 477 m: 0.234*** n = 306 f: 0.373*** n = 171 |
t: 0.261*** n = 470 m: 0.213*** n = 303 f: 0.362*** n = 167 |
m: 0.137* n = 292 |
t: 0.217*** n = 461 m: 0.193*** n = 295 f: 0.279*** n = 167 |
| MMP3 |
t: 0.212*** n = 471 m: 0.274*** n = 303 |
t: 0.355*** n = 471 m: 0.350*** n = 303 f: 0.439*** n = 168 |
t: 0.382*** n = 464 m: 0.387*** n = 300 f: 0.456*** n = 164 |
t: 0.187*** n = 446 m: 0.229*** n = 289 |
t: 0.308*** n = 455 m: 0.297*** n = 292 f: 0.424*** n = 163 |
| MMP9 | n.s. | m: −0.124* n = 271 | n.s. | n.s. | n.s. |
| SCF |
t: 0.204*** n = 478 m: 0.216*** n = 308 f: 0.184* n = 170 |
t: 0.464*** n = 478 m: 0.439*** n = 308 f: 0.502*** n = 170 |
t: 0.469*** n = 471 m: 0.421*** n = 305 f: 0.539*** n = 166 |
t: 0.198*** n = 453 m: 0.178** n = 294 f: 0.239** n = 159 |
t: 0.448*** n = 461 m: 0.440*** n = 296 f: 0.475*** n = 165 |
| TNF-alpha | n.s. | f: 0.402** n = 59 | f: 0.293* n = 57 | n.s. | n.s. |
| VEGF |
t: 0.222*** n = 478 m: 0.226*** n = 308 f: 0.215** n = 170 |
t: 0.198*** n = 478 m: 0.206*** n = 308 f: 0.237** n = 170 |
t: 0.184*** n = 471 m: 0.207*** n = 305 f: 0.195* n = 166 |
t: 0.139** n = 454 m: 0.162** n = 294 |
t: 0.121** n = 463 m: 0.151** n = 297 |
Pearson correlation: *p < 0.05; **p < 0.01; ***p ≤ 0.001.
t total cohort, m males only, f females only, n.s. not significant.