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. 2023 Mar 11;14:1340. doi: 10.1038/s41467-023-37030-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Transcriptome analysis on differential expression between responders (n = 10) and non-responders (n = 18), DESeq2 was provided to perform differential expression testing using the Wald test, multiple testing was adjusted using Benjamini and Hochberg method. B The abundance of predefined 14 immune cells composition between responders (n = 10) and non-responders (n = 18), box plots are indicated in terms of minima, maxima, centre, bounds of box and whiskers (interquartile range value), and percentile in the style of Tukey. Wilcoxon test was used to determine the statistical significance between subgroups. The adverse predictive value of tumor-infiltrating MCs in immuno-chemotherapy, p-values were based on a two-sided log-rank test for survival analysis. E Higher tumor-infiltrating MCs in immuno-chemotherapy presented worse ORR, 2 patients achieved PR in the high (median) tumor-infiltrating MCs group (n = 14), and 8 patients achieved PR in the low (median) tumor-infiltrating MCs group (n = 14). Fisher’s exact test was used to determine the statistical significance between the two groups. Source data are provided as a Source Data file.