Table 3.
HGS, mGPS, and liver cancer overall survival stratified by body mass index, tumor stage, age, sex, smoking, and alcohol consumption.
| Stratification variable | Univariate analysis | Multivariate analysis | p for interaction | ||
|---|---|---|---|---|---|
| HR (95%CI) | p-value | HR (95%CI) | p-value | ||
| Tumor stage | 0.478 | ||||
| I | 3.81 (0.92–15.74) | 0.065 | 4.01 (0.79–20.37) | 0.094 | |
| II | 2.96 (1.18–7.43) | 0.021 | 3.26 (1.10–9.66) | 0.033 | |
| III | 2.70 (1.03–7.06) | 0.043 | 2.94 (1.11–7.77) | 0.030 | |
| IV | 2.66 (1.45–4.90) | 0.002 | 2.26 (1.19–4.29) | 0.013 | |
| Age | 0.936 | ||||
| <65 | 3.17 (1.95–5.13) | <0.001 | 2.16 (1.30–3.60) | 0.003 | |
| ≥65 | 3.98 (1.57–10.09) | 0.004 | 3.48 (1.31–9.19) | 0.012 | |
| Sex | 0.207 | ||||
| Man | 3.23 (2.04–5.11) | <0.001 | 1.99 (1.22–3.25) | 0.006 | |
| Woman | 5.47 (2.08–14.39) | 0.001 | 4.04 (1.46–11.17) | 0.007 | |
| Smoking | 0.637 | ||||
| Yes | 2.26 (1.10–4.66) | 0.027 | 2.00 (0.89–4.52) | 0.095 | |
| No | 3.50 (0.83–14.78) | 0.088 | 2.90 (0.61–13.68) | 0.179 | |
| Other | 4.72 (2.69–8.28) | <0.001 | 2.59 (1.43–4.72) | 0.002 | |
| Alcohol consumption | 0.327 | ||||
| Yes | 2.36 (1.09–5.12) | 0.029 | 2.01 (0.91–4.46) | 0.084 | |
| No | 4.12 (2.52–6.74) | <0.001 | 2.44 (1.45–4.13) | 0.001 | |
| BMI | 1.000 | ||||
| <18.5 | 1.45 (0.43–4.85) | 0.550 | 1.39 (0.31–6.32) | 0.669 | |
| 18.5–24.9 | 3.46 (2.12–5.65) | <0.001 | 2.28 (1.36–3.82) | 0.002 | |
| ≥25 | 1.77 (1.28–2.44) | 0.001 | 1.55 (1.08–2.22) | 0.017 | |
Cox proportional hazards multiple models adjust for BMI categories (<18.5,18.5–24.9,≥25), at-diagnosis values of age (years), sex (man or woman), tumor stage (I, II, III or IV), surgery (yes or no), chemotherapy (yes or no), radiotherapy, smoking (yes or no), alcohol (yes or no) and TSF, unless stratified by those variables. All HRs compare patients with low HGS and high mGPS vs patients with high HGS and low mGPS.