Table 1.
The tick bite history and clinical manifestation of patients enrolled in the study.
| Patient | Tick on patients/engorgement | HE staining of skin lesions | Clinical symptoms/laboratory tests | Interval from tick bite to skin sample collection (days) | Detected pathogens in skin or in blood | |
|---|---|---|---|---|---|---|
| Case 1 | Ixodes persulcatus/no engorgement | NA | No | 1 | JMTV | |
| Case 2 | Dermacentor silvarum/full engorgement | Necrosis | Local swollen | 10 | JMTV | |
| Case 3 | I. persulcatus/half engorgement | Inflammatory infiltration | No | NA | JMTV | |
| Case 4 | I. persulcatus/half engorgement | NA | No | 2 | JMTV, CRT, Roseomonas cervicalis, DTMV | |
| Case 5 | D. silvarum/full engorgement | NA | Itching | 3 | JMTV, Rickettsia raoultii | |
| Case 6 | Haemaphysalis concinna/no engorgement | NA | No | 1 | JMTV, CRT | |
| Case 7 | D. silvarum/full engorgement | Necrosis | Lymphadenectasis | 30 | JMTV, Roseomonas cervicalis, BLTV4 | |
| Case 8 | I. persulcatus/half engorgement | Inflammatory infiltration | Headache/neutropenia | 8 | JMTV, Coxiella burnetii | |
| Case 9 | D. silvarum/full engorgement | Necrosis | Lymphadenitis | 15 | JMTV, Rickettsia raoultii | |
| Case 10 | NA | Necrosis | Itching, eschar (hospitalization)/ALT and AST elevation | 10 | JMTV, Coxiella burnetii, BLTV4 | |
| Case 11 | NA | Inflammatory infiltration | Eschar | 5 | Rickettsia raoultii | |
| Case 12 | NA | Inflammatory infiltration | Fever, rash (hospitalization)/ALT elevation | 9 | No | |
| Case 13 | NA | Inflammatory infiltration | Fever, rash lymphadenitis/AST elevation | 14 | Rickettsia sibirica | |
| Case 14 | NA | Normal | No | 1 | No | |
NA, not available; CRT, Candidatus Rickettsia tarasevichiae; JMTV, Jingmen tick virus; DTMV, deer tick Mononegavirales-like virus; BLTV4, Bole tick virus 4; ALT, alanine aminotransferase; AST, aspartate aminotransferase; HE, hematoxylin and eosin.