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. 2023 Feb 27;14:1132621. doi: 10.3389/fendo.2023.1132621

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Copyright © 2023 Li, Zhang, Wei, Zhu, Yin and Wan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Volcanic maps under different detection modes show the distribution of different features. The blue dot represents the up regulated features while the red dot represents the down regulated. (A): positive ionization mode in HILIC; (B): negative ionization mode in HILIC; (C): positive ionization mode in RPLC; (D): negative ionization mode in RPLC; (E): Heatmap based on 44 metabolites, unsupervised cluster analysis showed that differential metabolites could distinguish DOR patients from healthy subjects.