Figure 1.

Epileptiform activity in 4-aminopyridine. The earliest pathological activity recorded in a horizontal brain slice prepared from a young adult, wild-type mouse, following application of 100 µM 4-aminopyridine (4AP). Note the prominent early discharges in the hippocampal territories, well in advance of the first seizure-like events (SLEs), that are far more prominent in the neocortex and entorhinal cortex (not shown). Seizure-like events are small in the hippocampus and appear to be secondary generalized from the entorhinal and neocortical areas. See Codadu et al for further details. ^20,21