Figure 2.

Epileptiform activity in zero Mg²⁺ bathing solution. The earliest pathological activity recorded in a horizontal brain slice prepared from a young adult, wild-type mouse, following wash-out of Mg²⁺ ions. Note the virtual absence of any hippocampal activity, until very late, when it starts to entrain the neocortical activity into what we have termed the late-recurrent discharge pattern. See Codadu et al ^20,21 for further details.