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. 2023 Feb 27;11:1029671. doi: 10.3389/fcell.2023.1029671

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Copyright © 2023 Zhao, Li, Wang, Zhou, Li, Bi, Wang, Wu, Huang, Peng, Tang, Pan, Wang, Chen and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The potential therapeutical applications of bioengineered MSC-exosomes for tissue regeneration and nanoscale delivery system. (A) The bioengineered MSC-exosomes loading with specific signaling molecules, such as proteins, RNAs, and nanoparticles can achieve repair and regenerative effects on various tissues. (B) The bioengineered MSC-exosomes can cross the BBB in the brain or to the tumor for the treatment of CNS diseases and cancer. (MSC, mesenchymal stem cells, BBB, blood-brain barrier, CNS, central nervous system).