TABLE 2.
Summary of research concerning exosome-loaded scaffold in wound repair.
| Exosome type | Model | Scaffold | Function | Reference | |
|---|---|---|---|---|---|
| fibrosarcoma cell line HT1080-Exos | In vitro study | A thermo-responsive polymer of poly(N-vinyl caprolactam) (PNVCL) for encapsulation of exosomes | facilitate thrombus degradation and healing of endothelium lining | Das et al. (2022) | |
| GMSCs-Exos | diabetic rats | GMSC-Derived Exosomes Combined with a Chitosan/Silk Hydrogel Sponge | promoting the re-epithelialization, deposition and remodeling of collagen and enhancing angiogenesis and neuronal ingrowth | Shi et al. (2017) | |
| hADMSCs-Exos | In vitro study | Elastomeric Scaffolds (polycaprolactone) | increasing the wound healing properties and collagen type I and vitronectin of the MSC, and improving the M2 phenotype of the macrophages | Chachques et al. (2021) | |
| BMSC-exosomes | chronic diabetic wound healing | BMSC-exosomes-loaded carboxyethyl chitosan (KimParaiso et al., 2011)-dialdehyde carboxymethyl cellulose (DCMC) hydrogel (MSC-exosomes@CEC-DCMC HG) | adjusted the wound inflammation microenvironment, promoted neovascularization, and accelerated wound healing in type 1 diabetic rats | Geng et al. (2022) | |
| ADMSC-exosomes | rat full-thickness skin injury model | AMSC-exosomes-loaded β-chitin nanofiber hydrogel | acceleration rate of wound closure | Liu et al. (2022) | |
Abbreviations: Exo: exosome; ADMSC: adipose-derived mesenchymal stem cell; GMSC: gingival mesenchymal stem cell.