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. Author manuscript; available in PMC: 2024 Feb 16.
Published in final edited form as: Mol Cell. 2023 Jan 25;83(4):523–538.e7. doi: 10.1016/j.molcel.2023.01.004

Figure 3 |. DNA replication -dependent and -independent sources of centromere HOR DNA breaks.

Figure 3 |

(A) Experimental schematic of time course following induction of quiescence through serum starvation in hTERT-RPE1 cells. (B, C) Quantification and representative images of exo-FISH performed at the indicated time points. Quantification was performed as in Figure 2. Scale bar represents 10 μm. FISH signal intensity is X10,000 arbitrary units (A.U.). At least 30 cells were imaged per experimental condition. The medians of each experimental condition were used to perform a two-sided unpaired t-test (*p<0.05, **p<0.01). Filled and empty circles indicate presence and absence, respectively. See also Figure S4.