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. 2023 Feb 21;66(5):3448–3459. doi: 10.1021/acs.jmedchem.2c01940

Figure 6.

Figure 6

(a) Comparison of the cytotoxic effect of 2 against HT29 and A549 cells in the absence and presence of light (λ = 400–700 nm, 23 mW cm–2, 28 J cm–2). Comparison of the cytotoxic effect of 2, 4, and 11 against (b) HT29 and (c) A549 cells. For the treatment with 2 and 4, light irradiation (λ = 400–700 nm, 23 mW cm–2, 28 J cm–2) was also applied. The concentrations for 4 and 11 were multiplied by 3 in the figures. For (a)–(c), data are expressed as the mean ± SEM of three independent experiments, each performed in quadruplicate. (d) Variation of the combination index with the IC value determined from the dose-dependent survival curves of 2, 4, and 11 against HT29 and A549 cells.