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. Author manuscript; available in PMC: 2023 Mar 13.
Published in final edited form as: Cell Metab. 2023 Mar 7;35(3):429–437.e5. doi: 10.1016/j.cmet.2023.02.005

Figure 1. Fgf21−/− mice have a prolonged righting reflex recovery time after a binge ethanol dose.

Figure 1.

(A) Plasma FGF21 concentrations were measured in wild-type (WT) mice either 1 hour before administering ethanol (5 g/kg, oral gavage) or at the indicated times after ethanol (n = 6 mice/group).

(B-E) WT and Fgf21−/− mice were administered ethanol (5 g/kg, oral gavage) and the following measurements made: time to loss of righting reflex (LORR) (B); LORR duration (C); plasma ethanol concentrations (D); brain ethanol concentrations (E) (n = 17 mice/group for (B) and (C) and 6 mice/group for (D) and (E)).

All data represent the mean ± SEM. *, P < 0.05, **, P < 0.01, ***, P < 0.001 compared to −1 hour (A; one-way ANOVA) or WT (C; Student’s t-test).