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. Author manuscript; available in PMC: 2023 Mar 13.
Published in final edited form as: Cell Metab. 2023 Mar 7;35(3):429–437.e5. doi: 10.1016/j.cmet.2023.02.005

Figure 2. Hepatocyte-specific Fgf21−/− and neuron-specific Klb−/− mice have prolonged righting reflex recovery times after a binge ethanol dose.

Figure 2.

Control (Fgf21fl/fl) and hepatocyte-specific Fgf21−/− (Fgf21Alb) mice (A-C) or control (Klbfl/fl) and neuron-specific Klb−/− (KlbCamk2a) mice (D-F) were administered ethanol (5 g/kg, oral gavage) and the following measurements made: time to loss of righting reflex (LORR) (A, D); LORR duration (B, E); and plasma ethanol concentrations (C, F) (n = 12–16 mice/group for A, B, D, E and 11–12 mice/group for C and 10–11 mice/group for F).

All data represent the mean ± SEM. P values in (B, D, E) by Student’s t-test.