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Primary sequence alignment of antibody CDR loops used for the library of β-hairpins (3D-model): analogs of pembrolizumab (1c–s), GY-14 (2a,b), tislelizumab (3a,b), durvalumab (4a,b), mAb59 (5), atezolizumab (6), and MW11-h317 (7). Regular and bulged hairpins (straps A and B) are presented in black and blue/red, respectively, with H-bonded residues underlined. Hydrophobic residues selected for substitutions by Gly are highlighted in magenta.
