Table 3.
Factors associated with continuation of oral PrEP at month 1 after initiation—Kisumu County, 2019–2021
| Complete case analysis | Imputed datasets | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Total |
Continuation 1 month n (%) |
Unadjusted OR (95% CI) |
p‐value |
Adjusted ORa (95% CI) |
p‐value |
Unadjusted OR (95% CI) |
p‐value |
Adjusted OR (95% CI) |
p‐value | |
| n=262 | n=96 | |||||||||
| Age (years) (N=262) | ||||||||||
| 15–24 | 87 | 24 (27.6) | 0.54 (0.31–0.95) | 0.03 | 0.46 (0.18–1.14) | 0.03 | 0.54 (0.31, 0.95) | 0.03 | 0.41 (0.21, 0.82) | 0.01 |
| ≥25 | 175 | 72 (41.1) | 1 | 1 | 1 | 1 | ||||
| Participant type (N=262) | ||||||||||
| General population | 180 | 58 (32.2) | 1 | 0.029 | 1 | 0.14 | 1 | 0.02 | 1 | 0.60 |
| Discordant couple | 82 | 38 (46.3) | 1.82 (1.06–3.10) | 1.2 (0.48–3.13) | 1.82 (1.06, 3.10) | 1.21 (0.59, 2.50) | ||||
| Marital status (N=244) | ||||||||||
| Single | 27 | 8 (29.6) | 0.61 (0.25–1.49) | 0.24 | 0.59 (0.24, 1.44) | 0.31 | ||||
| Cohabiting | 21 | 4 (19) | 0.34 (0.11–1.07) | 0.35 (0.11, 1.10) | ||||||
| Married monogamous | 145 | 59 (40.7) | 1 | 1 | ||||||
| Married polygamous | 41 | 15 (36.6) | 0.84 (0.41–1.72) | 0.88 (0.43, 1.82) | ||||||
| Separated/Divorced/Widowed | 10 | 5 (50) | 1.46 (0.40–5.46) | 1.49 (0.40, 5.55) | ||||||
| Referral source (N=248) | ||||||||||
| Voluntary counselling and testing | 83 | 21 (25.3) | 1 | <0.001 | 1 | 0.12 | 1 | 0.03 | 1 | 0.74 |
| Outpatient department | 113 | 54 (47.8) | 2.70 (1.46–5.01) | 1.31 (0.43–3.98) | 2.76 (1.49, 5.11) | 1.69 (0.74, 3.85) | ||||
| Maternal child health clinic | 19 | 9 (47.4) | 2.66 (0.94–7.45) | 1.77 (0.37–8.54) | 2.74 (0.98, 7.65) | 1.12 (0.32, 3.95) | ||||
| Partner notification services | 12 | 0 (0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | |||||
| Other programmes | 21 | 7 (33.3) | 1.48 (0.53–4.15) | 1.62 (0.23–1.24) | 1.57 (0.56, 4.4.41) | 1.17 (0.33, 4.08) | ||||
| Use of PrEP in preconception, antepartum and postpartum period (N=160) | ||||||||||
| Yes | 35 | 18 (51.4) | 2.9 (0.98–4.47) | 0.06 | 2.87 (0.96, 9.01) | 0.06 | 2.09 (1.04, 4.24) | 0.04 | 2.94 (0.98, 8.82) | 0.06 |
| No | 125 | 42 (33.6) | 1 | 1 | 1 | 1 | ||||
| Family planning use (N=147) | ||||||||||
| Yes | 67 | 24 (35.8) | 0.79 (0.41–1.55) | 0.501 | 0.79 (0.41, 1.55) | 0.5 | ||||
| No | 80 | 33 (41.3) | 1 | 1 | ||||||
| Period of initiation into PrEP care (N=261) | ||||||||||
| Quarter 1 (Nov–Dec 2019) | 9 | 2 (22) | 1 | <0.01 | 1 | 0.04 | 1 | 0.002 | 1 | 0.02 |
| Quarter 2 (Jan–Mar 2020) | 50 | 28 (56) | 0.73 (0.26, 2.01) | 0.42 (0.08, 1.96) | 0.74 (0.27, 2.02) | 0.81 (0.26, 2.54) | ||||
| Quarter 3 (Apr–Jun 2020) | 32 | 14 (44) | 0.92 (0.34, 2.44) | 0.33 (0.06, 1.48) | 0.93 (0.35, 2.47) | 0.96 (0.31, 3.00) | ||||
| Quarter 4 (Jul–Sep 2020) | 71 | 30 (42) | 0.47 (0.17, 1.24) | 0.29 (0.06, 1.28) | 0.48 (0.18, 1.26) | 0.73 (0.23, 2.25) | ||||
| Quarter 5 (Oct–Dec 2020) | 49 | 15 (31) | 0.26 (0.09, 0.74) | 0.06 (0.01, 0.46) | 0.27 (0.07, 0.77) | 0.25 (0.07, 0.89) | ||||
| Quarter 6 (Jan–Mar 2021) | 50 | 7 (14) | 0.16 (0.05, 0.50) | 0.13 (0.02, 0.70) | 0.17 (0.05, 0.52) | 0.20 (0.05, 0.74) | ||||
| Facility type (N=262) | ||||||||||
| County referral hospital | 82 | 14 (17.1) | <0.001 | <0.001 | <0.001 | <0.001 | ||||
| Sub‐county hospital | 180 | 82 (45.6) | 4.06 (2.18, 8.01) | 6.75 (2.34, 21.18) | 4.06 (2.13, 7.75) | 5.11 (2.24, 11.70) | ||||
Note: Missing data points for variables: Marital status n=28; Referral source n=14; Use of PrEP in preconception, antepartum and postpartum period n=102; Family planning use n=115; Period of initiation n=1.
aAdjusted OR (95% CI): Under complete case analysis, estimation of the parameter was based on 58.4 (153/262) of the total observations.