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. 2023 Mar 13;13:91. doi: 10.1038/s41398-023-02380-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Children with increased methylation of OXTR display reduced right amygdala-mPFC functional connectivity. A Z statistic map of voxels shows the significant main effect of age group (Children > Adults) in MNI space. The right amygdala seed region is depicted in gray. B Mean Z statistic values are plotted for each individual in the child cohort (n = 57) and adult (n = 23) cohort. ***P < 0.001. C Z statistic map of voxels shows the significant negative main effect of OXTRm depicted in MNI space. The right amygdala seed region is depicted in gray. D Mean Z statistic values are plotted against percent OXTRm for each participant (n = 57). Gray shading indicates 95% confidence interval around the best-fit line. E Mean Z statistic values are plotted against parent-reported self-control scores for each participant (n = 50). Gray shading indicates 95% confidence interval around the best-fit line.