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. 2023 Mar 13;14:1371. doi: 10.1038/s41467-023-36702-x

Fig. 2. Molecular models of chimeric prM and Tissue Culture Adaptive Mutations.

Fig. 2

a The immature DENV2/4EDII virion, which is composed of 60 prM+E trimers, is shown beside a trimer of prM+E and a monomer of prM+E glycoproteins. The E glycoprotein is represented in dark blue (EDI), yellow(EDII) and medium blue(EDIII) spheres with the stem and membrane alpha-helixes in dark blue ribbon. The DENV4 portion of the chimeric prM, aa 1-107, is shown in tan spheres and the DENV2 portion, aa 108-166, in orange ribbon. The TC change at aa89 is denoted by a pink sphere. b The mature DENV2/4EDII virion is composed of 30 rafts, each holding 3 E glycoprotein homodimers. The raft-raft boarder is enlarged in first a spheres and then a ribbon depiction. TC changes G177D (pink) and H230N (red), which converted a DENV2-G to a DENV4-D at 177 and a DENV4-H to a DENV2-N are shown.