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. 2023 Mar 13;14:1371. doi: 10.1038/s41467-023-36702-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Both DENV2/4 chimeras are slightly attenuated compared to parental DENV2 and DENV4 but replicate efficiently in Vero-81 cells. Mean + /- SD of triplicate values shown. b DENV2/4EDII replicates efficiently human macrophage cell line U937 + DC-SIGN but is slightly attenuated compared to parental DENV2 and DENV4. Mean + /- SD of triplicate values shown. c Both DENV2/4 chimeras are neutralized by DENV2 mAbs 2D22 and 3F9 as well as DENV4 mAbs 126 and 131. Cross-reactive neutralizing epitopes for hmAbs1 EDE1-C8 and EDE2-B7 are also retained. EC₅₀ values from Vero-81 focus reduction neutralization test (FRNT). EC₅₀ value denotes the amount of hmAb needed to neutralize 50% of the virus. d The DENV2/4EDII chimera contains epitopes targeted by DENV2 primary sera. Vero-81 FRNT EC₅₀ values of DENV2ic, DENV4ic and DENV2/4EDII. e The DENV2/4EDII chimera contains epitopes targeted by DENV4 primary sera. Vero-81 FRNT EC₅₀ values of DENV2ic, DENV4ic and DENV2/4EDII.