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. 2023 Mar 13;14:1371. doi: 10.1038/s41467-023-36702-x

Fig. 5. DENV2/4EDII induced Type Specific (TS) antibodies to both parental DENV2 and DENV4 strains.

Fig. 5

a Type-Specific Abs to DENV2 were identified in DENV2 sera and DENV2/4EDII sera but not DENV4 sera. Sera was depleted by BSA(control), DENV2 or DENV2 + DENV4 virions. Background (DV2 + DV4 depl) subtracted Vero-81 FRNT EC50 values are shown. Individual EC50 values are shown with a bar at the median value. Neutralization curves for each EC50 are shown in supplementary Fig. 4. b Type-Specific Abs to DENV4 were identified in DENV4 and DENV2/4EDII sera but not DENV2 sera. Sera was depleted with BSA(control), DENV4 or DENV2 + DENV4 virions. Background (DV2 + DV4 depl) subtracted Vero-81 FRNT EC50 values are shown. Individual EC50 values are shown with a bar at the median value. Neutralization curves for each EC50 are shown in supplementary Fig. 5. c Table shows the percent of Type-Specific Abs to DENV2 or DENV4 as compared to the BSA-depleted controls. 100*(heterologous depleted sera EC50 – DENV2 + DENV4 depleted sera EC50)/(BSA depleted sera EC50 – DENV2 + DENV4 depleted sera EC50).