TABLE 2.
Distribution of genotypes and allele frequencies and their association with Angio− and Angio+ groups
| Frequency | Univariate regression (odds ratio 95% CI) p‐value | Multivariate regression (odds ratio 95% CI) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Healthy | Angio− | Angio+ | p | Healthy | Angio− | Angio+ | Healthy | Angio− | Angio+ | |
| Rs1748195 | 0.101 | |||||||||
| AA | 102 (32.6) | 25 (50) | 42 (33.9) | Ref | Ref | Ref | Ref | Ref | Ref | |
| AC | 146 (46.6) | 19 (38) | 63 (50.8) | Ref | 0.53 (0.28, 1.01) 0.055 | 1.05 (0.66, 1.67) 0.844 | Ref | 0.50 (0.17, 1.43) 0.196 | 0.68 (0.28, 1.61) 0.378 | |
| CC | 65 (20.8) | 6 (12) | 19 (15.3) | Ref | 0.38 (0.15, 0.97) 0.043* | 0.71 (0.38, 1.33) 0.282 | Ref | 0.49 (0.22, 1.11) 0.089 | 0.92 (0.47, 1.79) 0.808 | |
| Dominant | 0.054 | |||||||||
| AA | 102 (32.6) | 25 (50) | 42 (33.9) | Ref | Ref | Ref | Ref | Ref | Ref | |
| AC + CC | 211 (67.4) | 25 (50) | 82 (66.1) | Ref | 0.48 (0.26, 0.88) 0.018* | 0.94 (0.61, 1.47) 0.797 | Ref | 0.49 (0.23, 1.04) 0.064 | 0.85 (0.45, 1.59) 0.603 | |
| Recessive | 0.192 | |||||||||
| AA + AC | 248 (79.2) | 44 (88) | 105 (84.7) | Ref | Ref | Ref | Ref | Ref | Ref | |
| CC | 65 (20.8) | 6 (12) | 19 (15.3) | Ref | 0.52 (0.21, 1.27) 0.153 | 0.69 (0.39, 1.21) 0.195 | Ref | 0.73 (0.27, 1.94) 0.529 | 0.71 (0.33, 1.54) 0.384 | |
| Additive | 0.088 | |||||||||
| AA | 102 (61.1) | 25 (80.6) | 42 (68.9) | Ref | Ref | Ref | Ref | Ref | Ref | |
| CC | 65 (38.9) | 6 (19.4) | 19 (31.1) | Ref | 0.38 (0.15, 0.97) 0.043* | 0.71 (0.38, 1.33) 0.282 | Ref | 0.43 (0.14, 1.33) 0.144 | 0.78 (0.31, 1.93) 0.587 | |
| Codominant | 0.308 | |||||||||
| AA + CC | 167 (53.4) | 31 (62) | 61 (49.2) | Ref | Ref | Ref | Ref | Ref | ||
| AC | 146 (46.6) | 19 (38) | 63 (50.8) | 0.70 (0.38, 1.29) 0.256 | 1.18 (0.78, 1.79) 0.433 | Ref | 0.63 (0.3, 1.32) 0.222 | 1.07 (0.59, 1.93) 0.824 | ||
| Allele | 0.044* | |||||||||
| A | 350 (55.9) | 69 (69) | 147 (59.3) | Ref | Ref | Ref | Ref | Ref | ||
| C | 276 (44.1) | 31 (31) | 101 (40.7) | 0.57 (0.36, 0.89) 0.015* | 0.87 (0.65, 1.17) 0.366 | Ref | 0.62 (0.39, 1.004) 0.052 | 0.91 (0.62, 1.34) 0.641 | ||
Note: Multivariate regression model adjusted with age, sex, BMI, Diabetes, HDL, TC, LD. Values are expressed as mean ± standard deviation or median (interquartile range 25th–75th) for normal and non‐normal distribution data respectively. *p ≤ 0.05 is indicates as significant.