Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Mar 13;56:11. doi: 10.1186/s40659-023-00423-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 7 — Summary and schematic representation of the study hypothesis. HFHS-induced lipotoxicity (untreated NAFP) downregulated the expression of miR-1976 and thereby upregulated the expression of pancreatic DDX58, NFκB1, and CHUK mRNAs. Activating the cGAS-STING signaling pathway stimulated diverse downstream signaling pathways including promoting the expression of inflammatory and fibrotic responses (NFκB1, Caspase-3, and increase in area percentage of collagen fibers). On benzyl propylene glycoside treatment, increased expression of miR-1976 inhibited the expression of its target genes (DDX58, NFκB1, and CHUK). Inhibiting the cGAS-STING signaling pathway reversed pathological disturbances manifested by decreased inflammation and fibrosis observed in the untreated NAFP. HFHS: high fat and high sucrose diet, NAFP: non-alcoholic fatty pancreas