Major Resources Table

Animals (in vivo studies)
Species	Vendor or Source	Background Strain	Sex	Persistent ID / URL
SIRPα Mt	Riken	C157BL/6	M/F	https://knowledge.brc.riken.jp/resource/animal/card?_Lang_=en&brc_no=RBRC01544
SIRPα tm1c (fl/fl)	Created from tm1a(EUCOMM)	C57BL/6	M/F	https://www.mousephenotype.org/data/genes/MGI:108563#order
Myh6 Cre	Jackson Labs			https://www.jax.org/strain/011038
Mck Cre	Jackson Labs			https://www.jax.org/strain/006475
Adipoq Cre	Jackson Labs			https://www.jax.org/strain/028020

Antibodies
Target antigen	Vendor or Source	Catalog #	Working concentration	Lot #	Persistent ID / URL
GAPDH	CST	5174	1:2000	D16H11	https://www.cellsignal.com/products/primary-antibodies/gapdh-d16h11-xp-rabbit-mab/5174
SIRPα	CST	13379	1:1000	D613M	https://www.cellsignal.com/product/productDetail.jsp?productId=13379
SIRPα	Santa Cruz Biotech	sc376884	IP: 4 μg/mg	C-7	https://www.scbt.com/p/sirp-alpha-antibody-c-7?requestFrom=search
pAKT (ser 473)	CST	4060	1:1000	D9E	https://www.cellsignal.com/product/productDetail.jsp?productId=4060
GLUT4	CST	2213	1:1000	1F8	https://www.cellsignal.com/product/productDetail.jsp?productId=2213
PI3K	CST	4257	1:1000	19H8	https://www.cellsignal.com/product/productDetail.jsp?productId=4257
pYIGF1R (Tyr1135/1136)/Insulin Receptor β (Tyr1150/1151)	CST	2969	1:1000	19H7	https://www.cellsignal.com/product/productDetail.jsp?productId=2969
Fibronectin	Sigma Aldrich	F3648	1:3000	Polyclonal	https://www.sigmaaldrich.com/US/en/product/sigma/f3648
αSMA	Sigma Aldrich	A5228	1:1000	FN-15	https://www.sigmaaldrich.com/US/en/produ t/sigma/a5228
IGF1R	Santa Cruz Biotechnology	sc81464	WB: 1:1000 IP: 4 μg/mg	7G11	https://www.scbt.com/p/igf-ir-antibody-7g11
IGF1R	CST	3027	1:1000	Polyclonal	https://www.cellsignal.com/products/primary-antibodies/igf-i-receptor-b-antibody/3027

DNA/cDNA Clones
Clone Name	Catalog#	Source / Repository	Persistent ID / URL
Green fluorescent protein (GFP) plasmid	VDC-1040	Lonza	https://bioscience.lonza.com/lonza_bs/US/en/Transfection/p/000000000000191671/pmaxCloning%E2%84%A2-Vector
SIRPα plasmid cDNA	MMM1013–9201146	Open Biosystems/Thermo Fisher	https://www.thermofisher.com/order/genome-database/details/gene-expression/Mm01268655_g1

Recombinant Protein
Name	Source / Repository	Persistent ID / URL
SIRPα	R&D Systems	https://www.rndsystems.com/products/recombinant-mouse-sirp-alpha-cd172a-fc-chimera-protein-cf_7154-sa

Cultured Cells
Name	Vendor or Source	Sex (F, M, or unknown)	Persistent ID / URL
C2C12	ATCC	unknown	https://www.atcc.org/products/crl-1772
HL-1	Dr. Jizhong Cheng-Baylor College of Medicine	unknown
3T3-L1	ATCC	unknown	https://www.atcc.org/products/cl-173

Reagents
Description	Source / Repository	Catalog#
Picrosirius Red Stain Kit	Polysciences	24901
Rneasy Fibrous Tissue Mini Kit	Qiagen	74704
Rnase-Free Dnase Set	Qiagen	79254
iScript cDNA Synthesis Kit	Bio-Rad	1708891
iQ SYBR Green Supermix	Bio-Rad	1708880
Phosphatase Inhibitor	Thermo Fisher Scientific	A32957
Protease Inhibitor	Roche	A32955
TRIzol	Thermo Fisher Scientific	15596026
RIPA Lysis & Extraction Buffer	G-Biosciences	786–489
Insulin	Eli Lilly	0002–8215

Randomization and Blinding
Experimental groups were allocated randomly, and investigators were blinded to group allocation when performing all data collection.