Fig. 3.
Moderate ethanol drinking does not alter cortical APP metabolism in APP/PS1 mice. There were no differences in a) cortical APP levels, b) cortical CTF -β levels, c) cortical CTF-α levels, d) cortical BACE-1 levels, or e) cortical ADAM-10 levels between H2O- and ethanol-treated APP/PS1 mice; f) There was a trend towards decreased IDE expression in ethanol-treated APP/PS1 mice compared to controls (unpaired t-test, p = 0.0968); g) Representative gels from Western blot experiments. Wildtype + EtOH, n = 7; APP/PS1 + EtOH, n = 8.