Table 1.
Baseline characteristics according to allocated group
| Characteristics | MB (n = 45) | Control (n = 46) |
|---|---|---|
| Age—years, median (IQR) | 46 (38–54) | 47 (31–60) |
| Female sex—no. (%) | 18 (40) | 18 (40) |
| Hypertension—no. (%) | 17 (38) | 18 (39) |
| Diabetes—no. (%) | 19 (42) | 17 (37) |
| Acute kidney injury—no. (%) | 22 (49) | 20 (44) |
| Infection source—no. (%) | ||
| Pneumonia—no. (%) | 22 (49) | 23 (50) |
| Intra-abdominal—no. (%) | 17 (38) | 18 (39) |
| Urinary tract—no. (%) | 4 (9) | 4 (9) |
| Other—no. (%) | 2 (4) | 1 (2) |
| Shock diagnosis to intervention—hours, mean (SD) | 8.3 ± 1.7 | 7.6 ± 2.3 |
| Positive fluid response at enrollment— no. (%) | 22 (49) | 20 (44) |
| Fluid load from shock diagnosis to intervention—ml/kg, mean (SD) | 24 ± 8.4 | 22 ± 9.6 |
| Heart rate, mean (SD) | 114 ± 9.9 | 115 ± 10.5 |
| Mean arterial pressure—mmHg, mean (SD) | 68 ± 4.5 | 67 ± 4.3 |
| Norepinephrine dose—mcg/kg/min), median (IQR) | 0.45 (0.27–0.68) | 0.37 (0.20–0.58) |
| Vasopressin use—no. (%) | 36 (80) | 34 (74) |
| Serum lactate—mmol/L, median (IQR) | 6.3 (4.8–7.4) | 5.0 (2.9–7.5) |
| Mechanical ventilation—no. (%) | 42 (93) | 38 (82) |
| ARDS—no. (%) | 36 (80) | 32 (70) |
| PaO2/FIO2 ratio (SD) | 190 ± 73 | 219 ± 79 |
| PEEP—cmH2O, IQR | 8 (6–8.5) | 7 (6–9) |
| Serum creatinine—mg/dL, median (IQR) | 1.5 (0.7–2.5) | 1.5 (0.8–2.1) |
| Serum bilirubin—mg/dL, median (IQR) | 1.4 (1.1–1.7) | 1.3 (0.8–1.6) |
| AST—mg/dL, median (IQR) | 113 (99–142) | 107 (75–163) |
| ALT—mg/dL, median (IQR) | 48 (41–78) | 39 (30–79) |
| Ejection fraction—%, median (IQR) | 61 (55–70) | 58 (54–66) |
| SOFA, median (IQR) | 10 (8–12) | 10 (8–12) |
| APACHE II, mean (SD) | 22.9 ± 4.4 | 22.4 ± 4.4 |
Plus–minus values are means ± standard deviation (SD); median with interquartile ranges (IQR) are in parentheses
MB methylene blue, ARDS acute respiratory distress syndrome, PEEP positive end-expiratory pressure, AST aspartate aminotransferase, ALT alanine aminotransferase, APACHE Acute Physiology and Chronic Health Evaluation