Table 2.
Outcomes according to allocated group
| Outcomes | MB (n = 45) | Control (n = 46) | Median difference (CI95) | p |
|---|---|---|---|---|
| Time to vasopressor discontinuation—hours, median (IQR) | 69 (59–83) | 94 (74–141) | 29.4 (15.4–50.7) | < 0.001 |
| Vasopressor-free days at 28 days, median (IQR) | 23.9 (0.0–24.8) | 19.5 (0.0–23.7) | 1.0 (0–4.1) | 0.008 |
| Cumulative fluid balance at 4 days, mean (SD) | 834 ± 1106 | 1575 ± 1040 | 741 (293–1188) | 0.001 |
| Days on mechanical ventilation, median (IQR) | 4.2 (3.3–5.1) | 5.1 (3.9–5.9) | 0.6 (− 0.06–1.2) | 0.075 |
| Serum lactate—mmol/L, median (IQR) | ||||
| 24 h | 2.9 (2.2–3.7) | 3.1 (2.6–6.0) | 0.5 (0.0–1.4) | 0.054 |
| 48 h | 1.7 (1.4–3.4) | 2.5 (1.1–3.3) | 0.3 (− 0.5–0.9) | 0.36 |
| 72 h | 1.4 (1.0–2.1) | 1.7 (0.5–3.1) | 0.0 (− 0.06–0.7) | 0.98 |
| ICU length of stay—days, median (IQR) | 6.6 (4.8–7.6) | 7.9 (5.0–10.0) | 1.5 (0.08–2.5) | 0.039 |
| Hospital length of stay—days, median (IQR) | 9.0 (6.3–9.3) | 10.5 (6.1–14.0) | 2.7 (0.3–4.6) | 0.027 |
| Relative Risk (CI95) | ||||
|---|---|---|---|---|
| Mortality at 28 days—no. (%) | 15/45 (33) | 21/46 (46) | 0.76 (0.55–1.05) | 0.23 |
Median with interquartile ranges are in parentheses
MB Methylene blue, CI confidence interval, ICU intensive care unit