Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Mar 13;1(5):329–345. doi: 10.1038/s44222-023-00039-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Springer Nature Limited 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

PMC Copyright notice

Fig. 2 — The intestine is organized into a crypt–villus architecture. The intestinal crypt contains crypt-base cell populations (such as intestinal stem cells and Paneth cells) and other differentiated cell types, including enterocytes, goblet cells and enteroendocrine cells. The niche is regulated by epithelial interactions with the surrounding mesenchymal/stromal cells and gradients of extracellular matrix (ECM) composition and soluble biochemical cues. BMP, bone morphogenetic protein.