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. 2023 Mar 13;1(5):329–345. doi: 10.1038/s44222-023-00039-3

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Fig. 5 — Initial conditions of engineered extracellular matrices (ECMs) can be tuned to adjust matrix stiffness, ECM composition (with or without full-length proteins such as laminin), integrin-binding motifs, degradability (matrix metalloproteinase degradable or hydrolytically degradable versus non-degradable) and stress relaxation. Each of these properties can be easily tuned with engineered ECMs to better understand their role in organoid growth, differentiation and morphogenesis. RGD, arginylglycylaspartic acid.