FIGURE 2.

CSGs in TCGA. A, UMAP projection of TCGA samples into two-dimensional space. Samples are clustered using k-means into CSGs represented by distinct colors. B, Distribution of CSG groups within the cancer types. C, Heatmap showing the expression of the individual Activator and Responder genes, samples clustered by CSG. Annotation bars represent the mean values of genes summarized by Activator or Responder labels. D, Boxplots showing wGII (a CIN measure), TILs, and TMB, by CSG. E, Multivariate Cox proportional hazards model including CSG, wGII, TMB, stage, and cancer type as covariates, showing improved outcome in CSG-3.