TABLE 4.
Group B meningococcus competitive bactericidal assaya
| MAb | IC50 (μg/ml) of polysaccharide competitors
|
CRI (N-Pr/B [%]) | ||
|---|---|---|---|---|
| N-Pr PS | B PS | C PS | ||
| A74 | 0.218 | 616 | >800 | 0.035 |
| A79 | 0.011 | 4.57 | 107 | 0.24 |
| A98 | 0.129 | 263 | >800 | 0.05 |
| 30H12 | >800 | 9.77 | >800 | <1.2 (B/N-Pr) |
a
The bactericidal activities of A74, A79, A98, and 30H12 antibodies were specifically inhibited by the N-Pr PS. As the bactericidal activity of 30H12 was very specific for B PS, we expressed the cross-reactivity index (CRI) as the B/N-Pr ratio for this antibody.