FIGURE 1.

Relationship between pelabresib and platelet count values. A, Day 14 platelet count as a function of steady state AUC of pelabresib. B, Day 14 mean platelet count as a percent of baseline compared with pelabresib mean AUC. The coefficient of determination (R²) = 0.8122, obtained from a simple linear regression model with mean platelet count ratio as the dependent variable and pelabresib capsule dose as the independent variable (tablet doses were multiplied by 1.34 to convert to capsule doses). C, Mean platelet count over time. AUC, area under the curve; CPI-0610, pelabresib; CXDX, Cycle number Day number; X mg C, Capsule pelabresib dose; X mg T, Tablet pelabresib dose.