Table 3.

MHC-1 induction in COLO-205 cells by synthetic cannabinoids.

Family	Molecular Weight	Compounds in Family	Compounds with ≥3X MHC-I Induction	Range of Induction (Fold)	EC50 (µM)
1	300 – 500	131	20	0.6 – 5.6	13
2	300 – 410	85	14	0.5 – 6.8	13
3	330 – 440	67	13	1.1 – 7.0	27
4	500 – 550	2	2	4.0 – 5.8	23
5	300 – 390	23	1	0.9 – 3.2	10
6	290 – 420	15	1	1.1 – 4.2	23
7	295 – 415	26	2	0.17 – 3.17	ND

Fold induction, MFI of cannabinoid-treated cells at maximum induction/MFI of vehicle-treated cells.

EC₅₀, effective concentration, 50% of maximum, of most potent cannabinoid in each family.

ND, not determined.