. 2023 Mar 13;131(3):037008. doi: 10.1289/EHP10710

Table 4.

Association between genetic risk and incident rheumatoid arthritis (RA) among UK Biobank participants ( $N =$ 342,973; $n =$ 2,034 incident RA cases).

Polygenic risk score^a	Case/ $n$	HR (95% CI) of incident RA		$p_{Trend}$
Polygenic risk score^a	Case/ $n$	Model 1^b	Model 2^c	$p_{Trend}$
Per standard deviation increment	—	1.22 (1.17, 1.27)	1.22 (1.17, 1.27)
Low genetic risk	554/113,181	Ref	Ref	$2.63 \times 10^{- 13}$
Intermediate genetic risk	640/113,181	1.16 (1.03, 1.29)	1.16 (1.04, 1.30)
High genetic risk	840/116,611	1.48 (1.33, 1.65)	1.48 (1.33, 1.65)

Note: —, not applicable; CI, confidence interval; HR, hazard risk; PRS, polygenic risk score; Ref, reference.

^{^a}

PRS ranges: low genetic risk (tertile 1): ( $negative 3.524$ to $negative 0.497$ ); intermediate genetic risk (tertile 2): ( $negative 0.498$ to 0.297); high genetic risk (tertile 3): (0.298 to 5.066). $Mean \pm standard deviation$ of PRS is $0 \pm 1$ .

^{^b}

Adjusted for age, sex, first 10 genetic principal components, and genotyping batch.

^{^c}

Adjusted for age, sex, UK Biobank assessment center, household income, education level, smoking status, body mass index, alcohol consumption, sedentary time, physical activity duration, healthy diet score, PRS, first 10 genetic principal components, and genotyping batch.