Table 5.
Replicated MR analysis by IVW method after removing confounders-related IVs.
| Exposure | Outcome | p-value | OR (95% CI) |
|---|---|---|---|
| Phylum | |||
| Actinobacteria (ID: 400) | Generalized epilepsy | 0.132 | 1.318 (0.920, 1.889) |
| Verrucomicrobia (ID: 3982) | Focal epilepsy | 0.017 | 1.697 (1.101, 2.616) |
| Class | |||
| Betaproteobacteria(ID: 2867) | Epilepsy | 0.001 | 1.381 (1.136, 1.679) |
| Verrucomicrobiae (ID: 4029) | Epilepsy | 0.030 | 1.186 (1.016, 1.384) |
| Bacilli (ID: 1673) | Generalized epilepsy | 0.025 | 0.718 (0.537, 0.960) |
| Verrucomicrobiae (ID: 4029) | Focal epilepsy | 0.008 | 1.900 (1.178, 3.063) |
| Order | |||
| Burkholderiales (ID: 2874) | Epilepsy | 0.002 | 1.359 (1.121, 1.648) |
| Verrucomicrobiales (ID: 4030) | Epilepsy | 0.030 | 1.186 (1.016, 1.384) |
| Verrucomicrobiales (ID: 4030) | Focal epilepsy | 0.008 | 1.900 (1.178, 3.063) |
| Family | |||
| Verrucomicrobiaceae (ID: 4036) | Epilepsy | 0.030 | 1.186 (1.016, 1.385) |
| Verrucomicrobiaceae (ID: 4036) | Focal epilepsy | 0.008 | 1.900 (1.178, 3.063) |
| Genus | |||
| Eubacterium Xylanophilus Group (ID: 14375) | Epilepsy | 0.014 | 0.816 (0.694, 0.959) |
| Akkermansia (ID: 4037) | Epilepsy | 0.030 | 1.186 (1.017, 1.385) |
| Anaerotruncus (ID: 2054) | Epilepsy | 0.011 | 1.238 (1.050, 1.459) |
| Ruminococcaceae UCG014(ID: 11371) | Epilepsy | 0.030 | 1.178 (1.016, 1.367) |
| Unknown genus (ID: 826) | Epilepsy | 0.004 | 0.819 (0.715, 0.939) |
| Bifidobacterium (ID: 436) | Generalized epilepsy | 0.036 | 1.389 (1.021, 1.890) |
| Coprobacter (ID: 949) | Generalized epilepsy | 0.044 | 0.787 (0.624, 0.993) |
| Unknown genus (ID: 826) | Generalized epilepsy | 0.005 | 0.682 (0.524, 0.889) |
| Akkermansia (ID: 4037) | Focal epilepsy | 0.008 | 1.899 (1.178, 3.062) |
| Alloprevotella (ID: 961) | Focal epilepsy | 0.025 | 1.499 (1.052, 2.137) |
| Clostridium Sensu Stricto 1(ID: 1873) | Focal epilepsy | 0.024 | 0.534 (0.310, 0.919) |
| Sutterella (ID: 2896) | Focal epilepsy | 0.032 | 1.715 (1.048, 2.806) |
OR, odds ratio; CI, confidence interval.