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. 2023 Feb 27;14:1117695. doi: 10.3389/fneur.2023.1117695

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Copyright © 2023 Calderón-Garcidueñas, Torres-Jardón, Greenough, Kulesza, González-Maciel, Reynoso-Robles, García-Alonso, Chávez-Franco, García-Rojas, Brito-Aguilar, Silva-Pereyra, Ayala, Stommel and Mukherjee.

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(A) Locus coeruleus (LC) neuron surrounded by loose neuropil (*) and myelinated axons (a). (B) An LC neuron with neuromelanin (Nm) structures containing nanoparticles (arrows) and similar NPs identified inside the nucleus (N). (C) Numerous NPs are identified both in large endolysosomal structures (long arrows) and in mitochondria (m) (short arrows). (D) The Golgi apparatus is a target of NPs, as well as the endoplasmic reticulum dilated structures (ER) (short arrows) and the lysosomal structures (long arrows).