Table 1.
Identity of hyperacetylated proteins involved in TCA cycle and mitochondrial electron transport in nSIRT3−/− mice (n = 6 nSIRT3−/− mice, n = 6 nSIRT3+/+ mice)
| Protein | Gene | Accession no. | No. of lysine mod sites |
|---|---|---|---|
| Aconitate hydratase, mitochondrial | Aco2 | Q99KI0 | 7 |
| ATP synthase F(0) complex subunit B1, mitochondrial | Atp5pb | Q9CQQ7 | 1 |
| ATP synthase protein 8 | Mtatp8 | P03930 | 1 |
| ATP synthase subunit alpha, mitochondrial | Atp5f1a | Q03265 | 8 |
| ATP synthase subunit beta, mitochondrial | Atp5f1b | P56480 | 6 |
| ATP synthase subunit epsilon, mitochondrial | Atp5f1e | P56382 | 1 |
| ATP synthase subunit O, mitochondrial | Atp5po | Q9DB20 | 3 |
| ATP synthase-coupling factor 6, mitochondrial | Atp5pf | P97450 | 1 |
| Citrate synthase, mitochondrial | Cs | Q9CZU6 | 8 |
| Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | Cox4i1 | P19783 | 1 |
| Cytochrome c1, heme protein, mitochondrial | Cyc1 | Q9D0M3 | 1 |
| Dihydrolipoyl dehydrogenase, mitochondrial | Dld | O08749 | 5 |
| Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial | Dlat | Q8BMF4 | 2 |
| Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondria | Dlst | Q9D2G2 | 1 |
| Fumarate hydratase, mitochondrial | Fh | P97807 | 2 |
| Hydroxyacylglutathione hydrolase, mitochondrial | Hagh | Q99KB8 | 1 |
| Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | Idh3a | Q9D6R2 | 6 |
| Isocitrate dehydrogenase [NAD] subunit γ 1, mitochondrial | Idh3g | P70404 | 2 |
| Malate dehydrogenase, mitochondrial | Mdh2 | P08249 | 5 |
| NAD-dependent malic enzyme, mitochondrial | Me2 | Q99KE1 | 1 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | Ndufa2 | Q9CQ75 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | Ndufa7 | Q9Z1P6 | 2 |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | Ndufa9 | Q9DC69 | 2 |
| NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | Ndufb11 | O09111 | 1 |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | Ndufs6 | P52503 | 1 |
| NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | Ndufs7 | Q9DC70 | 1 |
| NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | Ndufs1 | Q91VD9 | 2 |
| Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | Pdha1 | P35486 | 3 |
| Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial | Pdha2 | P35487 | 3 |
| Pyruvate dehydrogenase protein X component, mitochondrial | Pdhx | Q8BKZ9 | 3 |
| Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | Sdha | Q8K2B3 | 2 |
| Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | Sdhb | Q9CQA3 | 1 |
| Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial | Suclg1 | Q9WUM5 | 7 |
| Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial | Sucla2 | Q9Z2I9 | 3 |