Fig. 3. Associations between variants within the HLA locus and primary Sjögren syndrome.

A large number of variants that are associated with primary Sjögren syndrome (pSS) are located within the HLA locus on chromosome 6. The graph depicts chromosome position (x axis), odds ratio (OR; bubble size) and significance level (y axis) of these disease-associated genetic variants, which are coloured by study. Dotted lines indicate data generated from cohorts that included only patients with pSS who are positive for anti-SSA/Ro and/or anti-SSB/La autoantibodies. Linkage disequilibrium (expressed in terms of the squared correlation (R²)) between the depicted variants in Utah residents of northern and western European ancestry (a population of the 1000 Genomes Project, Code CEU) is indicated in the bottom triangle (data taken from LDlink²⁰⁶). Genes near the associated variants are annotated (using data from the UCSC Genome Browser on Human (GRCh37/hg19)²⁰⁷).