Table 2.
Characteristics of the 4 Adult Subtypes
| Characteristic | Total | Subtypes |
χ2 p-value |
|||
|---|---|---|---|---|---|---|
| A1 | A2 | A3 | A4 | |||
| No. of patients (%) | 23883 (100) | 9261 (38.8) | 129 (0.5) | 6705 (28.1) | 7788 (32.6) | |
| Age, Mean (SD), yr | 44.4 (18.2) | 36.3 (16.4) | 44.8 (15.5) | 55.1 (17.7) | 44.7 (15.7) | |
| Sex, No. (%) | ||||||
| Female | 19305 (80.8) | 7302 (78.8) | 106 (82.2) | 5387 (80.3) | 6510 (83.6) | |
| Race,# No. (%) | ||||||
| Asian | 173 (0.7) | 71 (0.8) | 1 (0.8) | 53 (0.8) | 48 (0.6) | ns |
| Black | 8037 (33.7) | 3199 (34.5) | 37 (28.7) | 2077 (31) | 2724 (35) | *** |
| White | 9770 (40.9) | 3925 (42.4) | 46 (35.7) | 2841 (42.4) | 2958 (38) | *** |
| American Indian or Alaska Native | 54 (0.2) | 23 (0.2) | 1 (0.8) | 11 (0.2) | 19 (0.2) | * |
| Native Hawaiian or Other Pacific Islander | 7 (0.1) | 7 (0.1) | 0 (0) | 0 (0) | 0 (0) | ns |
| Multiple races | 135 (5.7) | 52 (0.6) | 1 (0.8) | 53 (0.8) | 29 (0.4) | ns |
| Other^ | 4208 (17.6) | 1662 (17.9) | 29 (22.5) | 1191 (17.8) | 1326 (17) | *** |
| Comorbidities, No. (%) | ||||||
| Obesity | 11236 (47.0) | 1520 (16.4) | 82 (63.6) | 4612 (68.8) | 5022 (64.5) | *** |
| Allergic rhinitis | 4310 (18.0) | 670 (7.2) | 84 (65.1) | 729 (10.9) | 2827 (36.3) | *** |
| Sinusitis | 5136 (21.5) | 1284 (13.9) | 66 (51.2) | 1022 (15.2) | 2764 (35.5) | *** |
| Hypertension | 14118 (59.1) | 1916 (20.7) | 89 (69) | 6543 (97.6) | 5570 (71.5) | *** |
| Second hand smoke exposure | 284 (1.2) | 56 (0.6) | 4 (3.1) | 67 (1) | 157 (2) | ns |
| Depression | 7683 (32.2) | 1212 (13.1) | 54 (41.9) | 2821 (42.1) | 3596 (46.2) | *** |
| GERD | 9485 (39.7) | 997 (10.8) | 80 (62) | 4065 (60.6) | 4343 (55.8) | *** |
| Obstructive sleep apnea | 4476 (18.7) | 134 (1.4) | 60 (46.5) | 2034 (30.3) | 2248 (28.9) | *** |
| Eczema | 1468 (6.1) | 306 (3.3) | 20 (15.5) | 328 (4.9) | 814 (10.5) | *** |
| Pulmonary hypertension | 1825 (7.6) | 59 (0.6) | 13 (10.1) | 955 (14.2) | 798 (10.2) | *** |
| Environmental allergies | 1768 (7.4) | 424 (4.6) | 31 (24) | 324 (4.8) | 989 (12.7) | *** |
| Tobacco use disorder | 7284 (30.5) | 2515 (27.2) | 20 (15.5) | 1769 (26.4) | 2980 (38.3) | *** |
| Allergic bronchopulmonary aspergillosis | 26 (0.1) | 4 (0) | 2 (1.6) | 5 (0.1) | 15 (0.2) | ns |
| Drug Class, No. (%) | ||||||
| Systemic corticosteroid | 15947 (66.8) | 5668 (61.2) | 125 (96.9) | 3033 (45.2) | 7121 (91.4) | *** |
| Inhaled corticosteroid | 10955 (45.9) | 2020 (21.8) | 125 (96.9) | 1212 (18.1) | 7598 (97.6) | *** |
| Long-acting beta agonist | 7130 (29.9) | 711 (7.7) | 122 (94.6) | 581 (8.7) | 5716 (73.4) | *** |
| Allergy | 11372 (47.6) | 2390 (25.8) | 128 (99.2) | 1413 (21.1) | 7441 (95.5) | *** |
| Allergy & Asthma short-acting beta agonist | 5570 (23.3) | 926 (10) | 79 (61.2) | 692 (10.3) | 3873 (49.7) | *** |
| Biologic agent | 129 (0.5) | 0 (0) | 129 (100) | 0 (0) | 0 (0) | *** |
| Other controller | 1949 (8.2) | 81 (0.9) | 65 (50.4) | 138 (2.1) | 1665 (21.4) | *** |
| Other short-acting beta agonist | 20 (0.1) | 0 (0) | 1 (0.8) | 0 (0) | 19 (0.2) | ns |
*
p<0.05
**
p<0.01
***
p<0.001
#
ns=not significant, GERD = gastroesophageal reflux disease, Race - missing data not shown
^
Other = Other as defined by PCORnet common data model v6.0.