Table 1.

Analysis of tumor datasets with SOPRANO

Dataset	Tumor type	No. of individuals	Immunopeptidome
TCGA	33 tumor types	10,172	HLA-A0201, proto-HLA, patient specific
Lakatos	CRC, STAD, UCEC	879	Patient specific
Hartwig	Multiple	308	HLA-A0201, patient specific
Riaz	Melanoma	68	Patient specific

Four datasets were analyzed in this study, including a large cohort of 33 primary untreated tumor types obtained from TCGA; a cohort of primary untreated CRC, STAD and UCEC from TCGA with curated escaped mechanisms (Lakatos); an immunotherapy-treated metastatic tumor cohort from the Hartwig Medical Foundation (Hartwig); and a metastatic melanoma tumor cohort with genomic data pre and during immunotherapy (Riaz). The analysis was performed using different immunopeptidomes as described in the paper.