Extended Data Fig. 7. miniATAC-seq analysis of control and MERVL-KD embryos at two-cell, four-cell, and eight-cell stages.

(a) Schematic of sample collection for miniATAC-seq analysis in scrambled control and ASO-mediated MERVL-KD embryos. We supplied apparently healthiest embryos upon MERVL-KD for preparation of miniATAC-seq library. (b) Scatter plots showing the reproducibility between biological replicates in miniATAC-seq data. Pearson correlation values (R) are shown. (c) Track view of ATAC-seq read enrichments at a representative chromosomal position in all biological replicates. The y-axis represents normalized tag counts for ATAC-seq in each sample.