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. 2023 Mar 2;55(3):484–495. doi: 10.1038/s41588-023-01324-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — (a) Schematic of experimental procedure for CasRx-mediated KD of MERVL. (b) Representative images of smFISH and immunofluorescence staining for MERVL RNA (top) and MERVL-Gag protein (bottom) with DAPI counterstain in untargeted control and MERVL-KD two-cell stage embryos at 1.5 dpc, from 3 independent experiments. Scale bar: 20 µm. (c) Representative phase-contrast images of 4.5 dpc blastocysts upon untargeted control and MERVL-KD conditions, from 3 independent experiments. Scale bar: 100 µm. (d) Percentage of embryos by stages of development, upon untargeted control (n = 69) and MERVL-KD (n = 70) conditions. N.S., not significant; ***P < 0.001, chi-square test. Data for panel in d is available as source data.

Source data