Table 3.
Ranking table for all our network meta-analyses’ outcomes
| Early neurological improvement | ||||
| TNK 0.4 | ||||
| 0.93 [0.72; 1.19] | Alteplase | |||
| 0.84 [0.54; 1.29] | 0.90 [0.63; 1.29] | TNK 0.32 | ||
| 0.80 [0.56; 1.16] | 0.87 [0.66; 1.14] | 0.96 [0.66; 1.39] | TNK 0.1 | |
| 0.75 [0.55; 1.02] | 0.81 [0.67; 0.98] | 0.90 [0.63; 1.27] | 0.93 [0.72; 1.20] | TNK 0.25 |
| Excellent neurological recovery (mRS 0–1) | ||||
| TNK 0.4 | ||||
| 0.97 [0.70; 1.34] | TNK 0.1 | |||
| 0.90 [0.73; 1.10] | 0.93 [0.71; 1.21] | Alteplase | ||
| 0.86 [0.59; 1.26] | 0.89 [0.62; 1.26] | 0.96 [0.69; 1.33] | TNK 0.32 | |
| 0.79 [0.61; 1.02] | 0.81 [0.63; 1.06] | 0.88 [0.75; 1.03] | 0.92 [0.66; 1.27] | TNK 0.25 |
| Good neurological recovery (mRS 0–2) | ||||
| TNK 0.4 | ||||
| 0.83 [0.55; 1.26] | TNK 0.1 | |||
| 0.82 [0.52; 1.29] | 0.98 [0.66; 1.46] | TNK 0.32 | ||
| 0.81 [0.62; 1.07] | 0.98 [0.72; 1.33] | 0.99 [0.69; 1.43] | Alteplase | |
| 0.71 [0.51; 0.98] | 0.85 [0.63; 1.14] | 0.86 [0.60; 1.24] | 0.87 [0.72; 1.04] | TNK 0.25 |
| Poor neurological recovery (mRS 4–6) | ||||
| TNK 0.4 | ||||
| 0.96 [0.59; 1.58] | TNK 0.1 | |||
| 0.86 [0.68; 1.10] | 0.90 [0.56; 1.46] | Alteplase | ||
| 0.83 [0.43; 1.63] | 0.87 [0.44; 1.72] | 0.97 [0.50; 1.87] | TNK 0.32 | |
| 0.69 [0.45; 1.07] | 0.72 [0.40; 1.30] | 0.80 [0.55; 1.17] | 0.83 [0.39; 1.76] | TNK 0.4 |
| Partial/complete recanalization | ||||
| TNK 0.4 | ||||
| 0.97 [0.58; 1.61] | Alteplase | |||
| 0.84 [0.52; 1.37] | 0.87 [0.67; 1.14] | TNK 0.25 | ||
| Complete recanalization | ||||
| TNK 0.1 | ||||
| 0.64 [0.29; 1.40] | Alteplase | |||
| 0.47 [0.22; 0.99] | 0.73 [0.53; 1.01] | TNK 0.25 | ||
| All-cause mortality at 90 days | ||||
| TNK 0.25 | ||||
| 1.04 [0.45; 2.40] | TNK 0.1 | |||
| 0.99 [0.30; 3.30] | 0.96 [0.29; 3.12] | TNK 0.32 | ||
| 0.87 [0.59; 1.29] | 0.84 [0.38; 1.85] | 0.88 [0.27; 2.80] | Alteplase | |
| 0.66 [0.34; 1.29] | 0.64 [0.24; 1.66] | 0.67 [0.18; 2.41] | 0.76 [0.43; 1.35] | TNK 0.4 |
| Any intracranial hemorrhage | ||||
| TNK 0.25 | ||||
| 0.84 [0.53; 1.34] | Alteplase | |||
| 0.72 [0.29; 1.81] | 0.85 [0.35; 2.10] | TNK 0.1 | ||
| 0.54 [0.17; 1.71] | 0.64 [0.21; 2.01] | 0.75 [0.25; 2.30] | TNK 0.32 | |
| 0.55 [0.28; 1.07] | 0.65 [0.38; 1.11] | 0.76 [0.28; 2.04] | 1.00 [0.29; 3.43] | TNK 0.4 |
| Symptomatic intracranial hemorrhage | ||||
| TNK 0.25 | ||||
| 0.95 [0.60; 1.50] | Alteplase | |||
| 0.99 [0.28; 3.46] | 1.04 [0.31; 3.50] | TNK 0.1 | ||
| 0.93 [0.17; 5.05] | 0.98 [0.19; 5.15] | 0.94 [0.20; 4.32] | TNK 0.32 | |
| 0.57 [0.28; 1.19] | 0.60 [0.33; 1.11] | 0.58 [0.15; 2.19] | 0.62 [0.11; 3.56] | TNK 0.4 |
| Any parenchymal hematoma | ||||
| TNK 0.1 | ||||
| 0.66 [0.11; 4.08] | TNK 0.25 | |||
| 0.53 [0.09; 2.97] | 0.80 [0.39; 1.64] | Alteplase | ||
| 0.07 [0.01; 0.85] | 0.11 [0.02; 0.73] | 0.14 [0.03; 0.79] | TNK 0.4 | |
TNK Tenecteplase, all data are reported in risk ratio (RR) and 95% confidence interval (CI)