Table 3.
The results of quantitative analysis for the association between included variants and the risk of PD in different models.
| Gene | Variant | Sample size# | Allele | OR [95%CI] | ||
|---|---|---|---|---|---|---|
| Ref/Alt | Allele model | Dominant model | Recessive model | |||
| Genes of cytokines | ||||||
| TNF-α | rs1800629 | 6/1485/1464 | G/A | 1.12 [0.96, 1.30] | 1.11 [0.94, 1.31] | 1.33 [0.83, 2.13] |
| rs1799964 | 3/735/653 | T/C | 1.24 [0.85, 1.79] | 1.10 [0.70,1.72] | 3.19 [1.66,6.13]*** | |
| IL-1α | rs1800587 | 9/2129/2000 | C/T | 1.03[0.91,1.16] | 1.01 [0.88, 1.16] | 1.17 [0.84, 1.64] |
| IL-1β | rs16944 | 8/1857/1622 | C/T | 1.05 [0.85, 1.31] | 1.06 [0.84, 1.33] | 1.16 [0.77, 1.74] |
| IL-6 | rs1800795 | 4/924/1093 | G/C | 0.82 [0.63, 1.06] | 0.66 [0.55, 0.79]**** | 0.85 [0.55, 1.30] |
| IL-10 | rs1800896 | 6/1557/1540 | A/G | 1.00 [0.90, 1.11] | 1.04 [0.88, 1.23] | 0.94 [0.78, 1.14] |
| rs1800871 | 4/1472/1288 | C/A | 1.10 [0.98, 1.24] | 1.07 [0.89, 1.29] | 1.18 [0.98, 1.42] | |
| Genes involved in the oxidative stress | ||||||
| NOS1 | rs2682826 | 5/1246/1606 | C/T | 1.11 [0.89,1.38] | 1.11 [0.86,1.45] | 1.23 [0.92,1.66] |
| rs1060826 | 3/949/764 | G/A | 1.07 [0.86,1.34] | 1.14 [0.94,1.40] | 1.02 [0.53, 1.96] | |
| MnSOD | rs4880 | 3/409/253 | T/C | 1.14 [0.86, 1.53] | 1.08 [0.71, 1.64] | 1.52 [0.82, 2.82] |
| NFE2L2 | rs6706649 | 4/2048/1869 | G/A | 1.02 [0.88, 1.19] | 0.99 [0.84, 1.17] | 1.44 [0.82, 2.52] |
| rs6721961 | 4/2076/1873 | C/A | 1.02[0.91,1.14] | 1.01 [0.88,1.16] | 1.04 [0.79,1.35] | |
| rs35652124 | 4/2076/1868 | A/G | 1.03 [0.93, 1.13] | 0.99 [0.81,1.21] | 1.10 [0.92,1.31] | |
| rs2706110 | 3/2399/2191 | G/A | 1.06 [0.87, 1.30] | 1.08 [0.83, 1.41] | 0.99 [0.76, 1.30] | |
| rs10183914 | 3/2405/2210 | G/A | 0.95 [0.87, 1.04] | 0.95 [0.85, 1.07] | 0.91 [0.76, 1.08] | |
| rs1806649 | 3/2412/2199 | G/A | 0.92 [0.77, 1.11] | 0.94 [0.83, 1.07] | 0.90 [0.56, 1.46] | |
| rs2001350 | 3/2141/2207 | A/G | 1.06[0.92,1.23] | 1.09[0.83,1.43] | 1.27[0.67,2.42] | |
| Genes of neurotoxin-associated enzymes | ||||||
| CYP2D6 | rs3892097 | 14/1727/2087 | G/A | 1.14 [1.00, 1.29]* | 1.29 [1.02, 1.63]* | 1.06 [0.78, 1.44] |
| A2637 | 5/485/598 | A/- | 1.12 [0.58, 2.16] | 1.12 [0.58, 2.18] | NA | |
| PON1 | rs705379 | 3/908/1158 | C/T | 0.96 [0.85,1.08] | 0.97 [0.80,1.18] | 0.92 [0.75,1.12] |
| rs854560 | 11/2781/3176 | T/A | 1.20 [1.10, 1.30]*** | 1.21 [1.08, 1.35]*** | 1.37 [1.15, 1.62]*** | |
| rs662 | 10/2205/2538 | A/G | 1.01 [0.92, 1.10] | 0.99 [0.88,1.12] | 1.05 [0.88,1.24] | |
| CYP2E1 | rs2031920 | 3/454/501 | C/T | 1.13 [0.89, 1.44] | 1.14 [0.86, 1.52] | 1.31 [0.62, 2.76] |
| NAT2 | rs1799929 | 3/406/573 | C/T | 0.96 [0.80, 1.16] | 1.03 [0.79, 1.36] | 0.84 [0.59, 1.18] |
| rs1799930 | 3/405/573 | G/A | 1.02 [0.80, 1.30] | 1.02 [0.75, 1.37] | 1.06 [0.61, 1.83] | |
|
MDR1/
ABCB1 |
rs1128503 | 4/918/918 | C/T | 0.98 [0.86, 1.12] | 1.11 [0.91, 1.36] | 0.84 [0.59, 1.19] |
| rs1045642 | 10/2159/2753 | C/T | 1.06 [0.97, 1.15] | 1.04 [0.91, 1.19] | 1.12 [0.98, 1.28] | |
| rs2032582 | 7/1499/2091 | T/G(A) | 0.96 [0.87, 1.06] | 0.99 [0.83, 1.17] | 0.93 [0.80, 1.07] | |
| Genes of metabolism-associated enzymes | ||||||
| HFE | rs1800562 | 9/1644/4654 | G/A | 0.89 [0.73, 1.08] | 0.88[0.72, 1.08] | 0.93 [0.35, 2.51] |
| rs1799945 | 8/1217/4151 | C/G | 1.03 [0.89, 1.19] | 1.02 [0.87, 1.21] | 1.18 [0.70, 1.99] | |
| MTHFR | rs1801133 | 13/2250/2565 | C/T | 1.11 [0.93, 1.34] | 1.15 [0.90, 1.47] | 1.02 [0.85, 1.23] |
| rs1801131 | 4/550/527 | A/C | 1.05 [0.75, 1.47] | 0.97 [0.76, 1.23] | 0.77 [0.51, 1.14] | |
| Inflammatory polymorphic locus identified by genome-wide association studies (GWAS) study | ||||||
| BST1 | rs11724635 | 3/1293/1441 | C/A | 1.07 [0.96, 1.20] | 1.08 [0.92, 1.27] | 1.12 [0.92, 1.37] |
| rs11931532 | 3/1868/3782 | T/C | 0.90 [0.82, 0.99]* | 0.91 [0.78, 1.06] | 0.82 [0.70, 0.96]* | |
| HLA-DRB1 | rs660895 | 3/3041/4318 | A/G | 0.80 [0.74, 0.87]**** | 0.79 [0.71, 0.87]**** | 0.67 [0.52, 0.86]** |
| CCDC62 | rs12817488 | 3/1608/1649 | A/G | 0.80 [0.73, 0.89]*** | 0.77 [0.66, 0.89]*** | 0.74 [0.62, 0.87]*** |
# Number of articles/patients/controls included for quantitative analysis. The Allele (Ref/Alt) represents refer allele and alter allele, respectively. OR[95%CI] represents the odd ratios with 95% confidence interval. The values of OR [95%CI] in bold indicate statistically significant. The */**/***/**** represents the significant variants with p< 0.05, p<0.01, p<0.001, p<0.00001, respectively.