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. 2023 Mar 13;13:4172. doi: 10.1038/s41598-023-30582-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Mangiferin relieves liver injury induced by CCl4. (A) The diagram of treatment of mouse model. (B) Body weight. (C) The liver/body weight. (D) Serum ALT level. (E) Serum AST level. (F) Serum ALP level. (G) Serum TBA level. (H) Serum TBIL level. The mice were injected intraperitoneally 10% CCl4 (CCl4 was dissolved in olive oil) at dose of 2 mg/kg of body weight for 8 weeks, the control group mice were injected with an equal amount of olive oil. The mangiferin treatment group were injected intraperitoneally 10% CCl4 and orally administrated mangiferin at the dose of 50 mg/kg and 100 mg/kg (0.1 ml/10 g of body weight). Date are presented as means ± S.E.M. (n = 8). ###p < 0.001, compared with control group; *p < 0.05, **p < 0.01 and ***p < 0.001, compared with CCl4 group. Ctrl, control group; CCl4, carbon tetrachloride treated group; L-MF, low dose of mangiferin (50 mg/kg); H-MF, high dose of mangiferin (100 mg/kg).