Table 2.
Hazard ratios of diabetic peripheral neuropathy associated with metformin use and average daily dose of metformin use.
| Total | Case | Cases/PYs (/1000) | Crude Hazard Ratio (95% CI) | Adjusted Hazard Ratio* (95% CI) | |
|---|---|---|---|---|---|
| Non-metformin | 12,653 | 282 | 3.91 | 1.00 | 1.00 |
| Metformin | 37,052 | 1,651 | 7.12 | 1.80 (1.59, 2.04) | 1.84 (1.62, 2.10) |
| Daily dose, g | (Continuous) | 1.47 (1.44, 1.49) | 1.48 (1.46, 1.51) | ||
| <1.0 | 19,651 | 467 | 3.75 | 0.95 (0.82, 1.10) | 0.97 (0.84, 1.13) |
| 1.0-2.0 | 8,188 | 298 | 5.77 | 1.46 (1.24, 1.71) | 1.53 (1.30, 1.81) |
| >2.0 | 9,213 | 886 | 15.97 | 4.06 (3.55, 4.64) | 4.31 (3.76, 4.94) |
PY, person year; CI, confidence interval.
*Adjusted for sex, age at baseline, comorbidity index, number of visits and concomitant medication (vitamin B1 and B12, antihypertensive, antihyperlipidemic, and NSAIDs).