Table 3.
Hazard ratios of diabetic peripheral neuropathy associated with metformin use according to subgroups.
| Subgroups | Case | Total | Non-metformin (Ref) |
Metformin | P-int* | |
|---|---|---|---|---|---|---|
| Age, y | <60 | 1,065 | 26,367 | 1.00 | 2.29 (1.85, 2.84) | 0.005 |
| ≥60 | 868 | 23,338 | 1.00 | 1.57 (1.33, 1.84) | ||
| Sex | Male | 1,107 | 28,647 | 1.00 | 1.84 (1.56, 2.17) | 0.996 |
| Female | 826 | 21,058 | 1.00 | 1.85 (1.51, 2.28) | ||
| CI-index | 0 | 665 | 17,340 | 1.00 | 1.94 (1.56, 2.42) | 0.815 |
| 1 | 944 | 23,012 | 1.00 | 1.80 (1.49, 2.18) | ||
| ≥2 | 324 | 9,353 | 1.00 | 1.74 (1.30, 2.33) | ||
| Number of visits/y | 0 | 820 | 20,827 | 1.00 | 2.39 (1.92, 2.98) | 0.013 |
| 1-2 | 392 | 9,342 | 1.00 | 1.48 (1.13, 1.93) | ||
| >2 | 721 | 19,536 | 1.00 | 1.62 (1.32, 1.97) | ||
| Vitamin B12 | Not use | 1,892 | 48,451 | 1.00 | 1.84 (1.62, 2.10) | 0.820 |
| Use | 41 | 1,254 | 1.00 | 1.92 (0.79, 4.69) | ||
| Vitamin B1 | Not use | 1,202 | 32,789 | 1.00 | 2.02 (1.70, 2.39) | 0.068 |
| Use | 731 | 16,916 | 1.00 | 1.62 (1.33, 1.97) | ||
| Antihypertensive | Not use | 552 | 13,225 | 1.00 | 2.11 (1.62, 2.75) | 0.232 |
| Use | 1,381 | 36,480 | 1.00 | 1.75 (1.51, 2.02) | ||
| Antihyperlipidemic | Not use | 619 | 16,677 | 1.00 | 2.17 (1.74, 2.71) | 0.090 |
| Use | 1,314 | 33,028 | 1.00 | 1.68 (1.44, 1.97) | ||
| NSAIDs | Not use | 999 | 27,219 | 1.00 | 2.11 (1.75, 2.55) | 0.058 |
| Use | 934 | 22,486 | 1.00 | 1.60 (1.34, 1.91) |
*P-value for interaction tests.