Table 1.
Clinical characteristics of participating studies.
| Study name |
DM type |
Indi-viduals (N) |
Males (N, %) |
Age## [years] | BMI [kg/m2] | eGFRcreatinine
[ml/min/1.73 m2] |
SBP [mmHg] | Diabetes duration [years] | Urinary albumin | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| AER [mg/24h] |
UACR [mg/mmol] | ALB [mg/L] |
|||||||||
| AfterEU | T1D | 854 | 492 (57.60) |
43.67 (11.15) | 24.23 (3.21) |
89.48 (26.61) |
139.22 (20.90) | 28.02 (9.50) |
29.00 (7.00 - 618.00) |
NR | NR |
| UK-ROI | T1D | 1,410 | 716 (50.80) |
45.09 (11.35) | 26.30 (4.40) |
54.30 (30.00) |
135.02 (20.80) | 30.45 (9.70) |
NA | NA | NA |
| GENESIS | T1D | 1,324 | 700 (52.90) |
41.37 (12.21) | 22.21 (8.15) |
80.87 (28.49) |
129.41 (23.75) | 24.91 (10.45) | 9.00 (4.16-37.25) |
NR | NR |
| DiaGene | T2D | 1,886 | 1,011 (53.60) |
65.24 (10.57) | 30.47 (5.43) |
78.33 (20.55) |
141.83 (18.72) | 10.09 (8.45) |
NR | 5.85 (30.45) |
NR |
| Rotterdam | T2D | 1,022 | 487 (47.70) |
68.10 (9.70) | 29.40 (4.80) |
78.30 (16.40) |
147.10 (21.70) | NA | NA | NA | NA |
| ANDIS | T2D | 9,367 | 5,548 (59.22) |
66.29 (13.29) | 30.77 (5.70) |
84.69 (30.92) |
NA | 8.07 (4.40) |
NA | NA | NA |
| ExWas** | T2D | 3,990 | 2,370 (59.30) |
61.00 (8.50) |
NA | 79.00 (1.28) |
NA | NA | NA | NA | NA |
| UKBB- T2D# |
T2D | 14,890 | 9,703 (65.10) |
60.97 (6.28) |
31.90 (5.70) |
87.86 (15.73) |
144.50 (18.20) | NA | NR | NR | 16.00 (10.00-34.40) |
| UKBB-NDM# | NR* | 370,061 | 166,976 (45.10) | 56.73 (8.02) |
27.10 (4.50) |
90.81 (12.80) |
139.90 (19.60) | NR | NR | NR | 11.10 (8.30-18.10) |
*Non-DM population. **The ExWas study comprises summary data from T2D individuals (discovery set). N, sample size; SD, standard deviation; BMI, Body-Mass Index; eGFRcreatinine, estimated glomerular filtration rate based on the CKD-EPI2012 equation (non-transformed); SBP, Systolic blood pressure; AER, albumin excretion rate; IQR, Interquartile range; UACR, urinary albumin-creatinine ratio; UKBB, UK Biobank; ALB, continuous baseline urinary albumin level; T2D, Type 2 diabetes; DM, diabetes mellitus; NDM; non-DM; T1D, type 1 diabetes. NR, not relevant; NA, not available. #The UK Biobank urinary albumin measures are based on n=7,777 in T2D and n=370,061 in the NDM group. ##The time point for age assessment is NA for Genesis. Age at recruitment was used in all other studies. Age, BMI, eGFR, and SBP have been deonted as mean (SD), while Urinary albumin measures have been denoted as median (IQR).