Table 2.
meta-analysis of SNV-eGFRcreatinine summary data in diabetes mellitus and its subtypes (model 1).
| Genetic variant (EA) |
Diabetes type | N | Effect (Beta [95% CI]) |
PHET | P-value |
|---|---|---|---|---|---|
| rs144360241 (C) | T1D | 2,177 | -0.14 [-0.32; 0.05] | 0.38 | 0.15 |
| T2D | 30,727 | 0.01 [-0.01; 0.04] | 0.62 | 0.40 | |
| Combined DM | 32,904 | 0.01 [-0.02; 0.04] | 0.42 | 0.53 | |
| rs45551835 (A) | T1D | 3,236 | -0.02 [-0.13; 0.08] | 0.34 | 0.69 |
| T2D | 30,814 | 0.01 [0.00; 0.03] | 0.08 | 0.09 | |
| Combined DM | 34,050 | 0.01 [0.00; 0.02] | 0.15 | 0.10 | |
| rs141640975 (A) | T1D | 2,177 | 0.16 [-0.11; 0.44] | 0.75 | 0.25 |
| T2D | 30,816 | 0.00 [-0.03; 0.03] | 0.53 | 0.83 | |
| Combined DM | 32,993 | 0.01 [-0.02; 0.03] | 0.60 | 0.73 | |
| rs1801239 (C) | T1D | 3,236 | -0.01 [-0.06; 0.03] | 0.20 | 0.57 |
| T2D | 30,834 | 0.00 [0.00; 0.01] | 0.21 | 0.64 | |
| Combined DM | 34,070 | 0.00 [0.00; 0.01] | 0.23 | 0.59 |
SNV, single nucleotide variant; eGFRcreatinine, log-transformed estimated glomerular filtration rate based on the CKD-EPI2012 equation; EA, effect allele (i.e., minor allele); N, sample size; Beta, Beta coefficient; CI, confidence interval; PHet, P-value for heterogeneity across studies. PHet< 0.05 indicates variation; T1D: Type 1 diabetes; T2D: Type 2 diabetes; Combined DM: T1D and T2D combined.