Table 3.
meta-analysis of SNV-eGFRcreatinine summary data in diabetes mellitus and its subtypes (model 2).
| Genetic variant (EA) | Population | N | Effect (Beta [95% CI]) |
PHET | P-value |
|---|---|---|---|---|---|
| rs144360241 (C) | T1D | 1,916 | -0.12 [-0.32; 0.08] | 0.26 | 0.25 |
| T2D | 15,745 | 0.01 [-0.02; 0.04] | 0.37 | 0.66 | |
| Combined DM | 17,661 | 0.00 [-0.02; 0.03] | 0.32 | 0.78 | |
| rs45551835 (A) | T1D | 2,712 | -0.05 [-0.16; 0.07] | 0.25 | 0.43 |
| T2D | 15,724 | 0.01 [0.00; 0.03] | 0.03* | 0.14 | |
| Combined DM | 18,436 | 0.01 [0.00; 0.03] | 0.05 | 0.18 | |
| rs141640975 (A) | T1D | 1,916 | 0.10 [-0.17; 0.38] | 0.4 | 0.46 |
| T2D | 15,746 | 0.00 [-0.04; 0.05] | 0.58 | 0.88 | |
| Combined DM | 17,662 | 0.01 [-0.04; 0.05] | 0.67 | 0.8 | |
| rs1801239 (C) | T1D | 2,712 | 0.00 [-0.04; 0.05] | 0.53 | 0.94 |
| T2D | 15,741 | 0.00 [-0.01; 0.01] | 0.03* | 0.77 | |
| Combined DM | 18,453 | 0.00 [-0.01; 0.01] | 0.15 | 0.76 |
SNV, single nucleotide variant; eGFRcreatinine, log-transformed estimated glomerular filtration rate based on the CKD-EPI2012 equation; EA, effect allele (i.e., minor allele); N, sample size; Beta, Beta coefficient; CI, confidence interval; PHet, P-value for heterogeneity across studies. PHet< 0.05 indicates variation; T1D: Type 1 diabetes; T2D: Type 2 diabetes; Combined DM: T1D and T2D combined.