Table 7.

Summary results for GRS_CUBN-eGFR_creatinine and -ALB analyses in UKBB (model 3).

Trait	Population	N	Effect (Beta [SE])	P-value
ALB	NDM **	99,180	0.05 (0.004)	2 × 10-16*
	T2D ***	7,182	0.08 (0.02)	3 × 10-4 *
eGFRcreatinine	NDM	343,988	0.002 (0.0004)	2 × 10-5*
	T2D	13,828	0.005 (0.003)	0.1

GRS_CUBN, A genetic risk score based on a combination of the four CUBN genetic variants (minor alleles); N, sample size; Beta, Beta estimate; SE, standard error; ALB, continuous urinary albumin (mg/L, natural log-transformed); eGFR_creatinine, estimated glomerular filtration rate (natural log-transformed); NDM, without Diabetes Mellitus; T2D, Type 2 diabetes. *Statistically significant (P< 0.05). ** out of total 107,276 individuals with continuous urinary albumin levels. *** out of total 7,777 individuals with continuous urinary albumin levels.